2023
Xie, X., Zhai, J., Zhou, X., Guo, Z., Zhu, G., Lo, P.-C., Chan, K.W.Y. and Yang, M. (2023) Magnetic particle imaging: From tracers to biomedical applications. Adv. Matter. accepted
Deng, Z., Chen, S., Liu, G., and Zhu, G.* (2023) Unlocking the potential of platinum drugs: organelle-targeted small-molecule platinum complexes for improved anticancer performance. RSC Chem. Biol. 4, 1003–1013
[Invited review to themed collection on ‘Chemical Biology of Metals’]
Xu, Z., Lin, L., Fu, B., Hung, F.-P., Zhou, Q., Zhu, G., and Wang, Z. (2023) Ligand substitution reactions afford oxaliplatin-based platinum(IV) complexes bearing axial alkoxido ligands. Inorg. Chem. Front. 10, 6058–6066
Tang, X., Cheng, Y-T., Shen, J., Liu, J-H., Zhang, Z., Deng, Z., Lyu, F., Yang, Y., Zhu, G., Xu, Z., Lu, J., and Li, Y. Y. (2023) Supervariate ceramics: Demineralization via gelation in neutral nontoxic solutions. Adv. Eng. Mater. 2300430
Xue, Y., Ma, X., Feng, X., Roberts, S., Zhu, G., Huang, Y., Fan, X., Fan, J., and Chen, X. (2023) Temperature-derived purification of gold nano-bipyramids for colorimetric detection of tannic acid. ACS Appl. Nano Mater. 6, 11572–11580
Deng, Z.†, Li, H.†, Chen, S., Wang, N., Liu, G., Liu, D., Ou, W., Xu, F., Wang, X., Lei, D., Lo, P.-C., Li, Y. Y., Lu, J., Yang, M., He, M.-L.*, and Zhu, G.* (2023) Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner. Nat. Chem. 15, 930–939
[Highlighted as News & Views in Nat. Chem. 2023, 15, 896; news report in CityU News; Croucher News; Eurekalert; Bioengineer; ScienMag; MedicalXpress; NSFC; X-MOL; CityU WeChat (in Chinese)]
Liu, G., Zhang, Y., Yao, H., Deng, Z., Chen, S., Wang, Y., Peng, W., Sun, G., Tse, M.-K., Chen, X., Yue, J., Peng, Y.-K., Wang, L.*, and Zhu, G.* (2023) An ultrasound-activatable platinum prodrug for sono-sensitized chemotherapy. Sci. Adv. 9, eadg5964
[News report in X-MOL; iMedicines (in Chinese)]
Deng, Z. and Zhu, G.* (2023) Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands. Curr. Opin. Chem. Biol. 74, 102303
[Invited review to Metal-Based Cancer Therapeutics section]
Zhou, Q., Chen, S., Xu, Z., Liu, G., Zhang, S., Wang, Z., Tse, M.-K., Yiu, S.-M., and Zhu. G.* (2023) Multitargeted platinum(IV) anticancer complexes bearing pyridinyl ligands as axial leaving groups. Angew. Chem. Int. Ed. 62, e202302156
[News report in X-MOL; WileyChem (in Chinese)]
Tan, X.†, Deng, Z.†, Wang, Q., Chen, S., Zhu, G.*, Sun, J.* (2023) meta-Hydroxyl-directed asymmetric substitution via triaryl carbocations. Nat. Synth. 2, 275–285
[News report in X-MOL (in Chinese); CityU News]
Liu, Y., Yao, H., Tse, M.-K., Chen, S., Yiu, S.-M., and Zhu, G.* (2023) Synthesis, characterization, and cytotoxicity of a reactive platinum(IV) monotrifluoromethyl complex. Eur. J. Inorg. Chem. 26, e202200438
[Invited contribution to Institute Feature: Hong Kong Universities; Highlighted as Front Cover]
2022
Yao, H. and Zhu, G.* (2022) Blood components as carriers for small-molecule platinum anticancer drugs. ChemMedChem 17, e202200482
[Invited Review]
Kasparkova J., Kostrhunova H., Novohradsky V., Ma L., Zhu G., Milaeva E. R., Shtill A. A., Vinck, R., Gasser G., Brabec V., and Nazarov A. A. (2022) Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug? Metallomics 14, mfac048
Yan, Q., Duan, M., Chen, C., Deng, Z., Wu, M., Yu, P., He, M.*, Zhu, G.*, Houk, K. N.*, and Sun, J.* (2022) Organocatalytic discrimination of non-directing aryl and heteroaryl groups: enantioselective synthesis of bioactive indole-containing triarylmethanes. Chem. Sci. 13, 5767–5773
Yao, H., Wang, Z.*, Wang, N., Deng, Z., Liu, G., Zhou, J., Chen, S., Shi, J., and Zhu, G.* (2022) Enhancing circulation and tumor accumulation of carboplatin via an erythrocyte-anchored prodrug strategy. Angew. Chem. Int. Ed. 61, e202203838
Ma, L., Li, L., and Zhu, G.* (2022) Platinum-containing heterometallic complexes in cancer therapy: advances and perspectives. Inorg. Chem. Front. 9, 2424–2453
[Invited Review and highlighted as Outside Front Cover]
Yao, H., and Zhu, G.* (2022) A platinum-based fluorescent “turn on” sensor to decipher the reduction of platinum(IV) prodrugs. Dalton Trans. 51, 5394–5398
[Highlighted as Outside Front Cover]
Chen, S., Ng, K. Y., Zhou, Q., Yao, H., Deng, Z., Tse, M.-K., and Zhu, G.* (2022) The influence of different carbonate ligands on the hydrolytic stability and reduction of platinum(IV) prodrugs. Dalton Trans. 51, 885–897
Li, B., Liu, J., Lyu, F., Deng, Z., Yi, B., Du, P., Yao, X., Zhu, G., Xu, Z., Lu, J., and Li, Y. Y. (2022) Mineral hydrogel from inorganic salts: biocompatible synthesis, all-in-one charge storage, and possible implications in the origin of life. Adv. Funct. Mater. 32, 2109302
Xue, Y., Feng, X., Fan, X., Zhu, G., McLaughlan, J., Chen, X., and Zhang, W. (2022) Exosomes for early diagnosis of cancers. Small Struct. 3, 2100096
2021
Wang, N., Deng, Z., Zhu, Q., Zhao, J., Xie, K., Shi, P., Wang, Z., Chen, X., Wang, F., Shi, J., and Zhu, G.* (2021) An erythrocyte-delivered and near-infrared photoactivatable oxaliplatin nanoprodrug for enhanced antitumor efficacy and immune response. Chem. Sci. 12, 14353–14362 [Highlighted as Outside Front Cover]
Yao, H., Gunawan, Y. F., Liu, G., Tse, M.-K., and Zhu, G.* (2021) Optimization of axial ligands to promote the photoactivation of BODIPY-conjugated platinum(IV) anticancer prodrugs. Dalton Trans. 50, 13737–13747
Zhou, B., Ou, W., Zhao,C., Shen, J., Zhang, G., Tang, X., Deng, Z., Zhu, G., Li, Y. Y., Lu, J. (2021) Insertable and reusable SERS sensors for rapid on-site quality control of fish and meat products. Chem. Eng. J. 426, 130733
Qi, S., Zhang, Y., Liu, G., Chen, J., Li, X., Yang, Y., Shi, J., Lee, C.-S., Lai, P.*, Zhu, G.*, Wang, L.*, and Fang, C.* (2021) Plasmonic-doped melanin-mimic for CXCR4-targeted NIR-II photoacoustic computed tomography-guided photothermal ablation of orthotopic hepatocellular carcinoma. Acta Biomater. 129, 245–257
Xu, Z., Tang, W. K., Zhou, Q., Chen, S., Siu, C.-K.*, and Zhu, G.* (2021) On the hydrolytic stability of unsymmetric platinum(IV) anticancer prodrugs containing axial halogens. Inorg. Chem. Front. 8, 3794–3802 [Highlighted as Outside Front Cover]
Xu, Z., Deng, Z., Wang, Z., and Zhu, G.* (2021) Recent advances in the synthesis, stability, and activation of Pt(IV) prodrugs. Coord. Chem. Rev. 442, 213991
Deng, Z., Li, C., Chen, S., Zhou, Q., Xu, Z., Wang, Z., Yao, H., Hirao, H., and Zhu, G.* (2021) An intramolecular photoswitch can significantly promotes photoactivation of Pt(IV) prodrugs. Chem. Sci. 12, 6536–6542 [Highlighted as Back Cover]
Ren, B., Chen, B., Zhao, J., Guo, Y., Zhang X., Chen, X., Du, Y., Deng, Z., Zhu, G., and Wang, F. (2021) Synthesis of core–shell ScF3 nanoparticles for thermal enhancement of upconversion. Chem. Mater. 33, 158–163
Deng, Z., Wang, N., Ai, F., Wang, Z.*, and Zhu, G.* (2021) Nanomaterial-mediated platinum drug-based combinatorial cancer therapy. VIEW 2, 20200030 [Invited Review and Back Cover]
2020
Li, X.†, Duan, M.†, Deng, Z.†, Shao, Q., Chen, M., Zhu, G.*, Houk, K.N.*, and Sun, J.* (2020) Catalytic enantioselective synthesis of chiral tetraarylmethanes. Nat. Catal. 3, 1010–1019
Yao, H., Chen, S., Deng, Z., Tse, M.-K., Matsuda, Y., and Zhu, G.* (2020) BODI-Pt, a green-light activatable and carboplatin-based platinum(IV) anticancer prodrug with enhanced activation and cytotoxicity. Inorg. Chem. 59, 11823–11833
Chen, S., Yao, H., Zhou, Q., Tse, M.-K., Gunawan, Y. F., and Zhu, G.* (2020) Stability, reduction, and cytotoxicity of platinum(IV)-based anticancer prodrugs bearing carbamate axial ligands: Comparison with their carboxylate analogues. Inorg. Chem. 59, 11676–11687
Deng, Z., Wang, N., Liu, Y., Xu, Z., Wang, Z., Lau, T.-C., and Zhu, G.* (2020) A photocaged, water-oxidizing, and nucleolus-targeted Pt(IV) complex with a distinct anticancer mechanism. J. Am. Chem. Soc. 142, 7803–7812
[Highlighted as Supplementary Cover and in JACS Spotlights J. Am. Chem. Soc. 2020, 142, 8061; news report in X-MOL (in Chinese); highlighted in SYNFACTS]
Du, Y., Wang, Y., Deng, Z., Chen, X., Yang, X., Sun, T., Zhang, X., Zhu, G., Yu, S. F., and Wang, F. (2020) Blue-pumped deep ultraviolet lasing from lanthanide-doped Lu6O5F8 upconversion nanocrystals. Adv. Opt. Mater. 8, 1900968
2019
Xu, Z., Li, C., Zhou, Q., Deng, Z., Tong, Z., Tse, M.-K., and Zhu, G.* (2019) Synthesis, cytotoxicity, and mechanistic investigation of platinum(IV) anticancer prodrugs conjugated with poly(ADP-ribose) polymerase (PARP) inhibitors. Inorg. Chem. 58, 16279–16291
[Highlighted as Supplementary Cover]
Wang, Z.*, Wang, N., Cheng, S.-C., Xu, K., Deng, Z., Chen, S., Xu, Z., Xie, K., Tse, M.-K., Shi, P., Hirao, H., Ko, C.-C., and Zhu, G.* (2019) Phorbiplatin, a highly potent Pt(IV) antitumor prodrug that can be controllably activated by red light. Chem 5, 3151–316
[News report in CityU News; CityU Today; X-MOL (in Chinese); ScienceDaily; Eurekalert; Phys.org; CityU_research (in Chinese); and many other local news]
Yan, L., Gonca, S., Zhu, G., Zhang, W., and Chen, X. (2019) Layered double hydroxide nanostructures and nanocomposites for biomedical applications. J. Mater. Chem. B 7, 5583–5601
Yao, H., Xu, Z., Li, C., Tse, M.-K., Tong, Z., and Zhu, G.* (2019) Synthesis and cytotoxic study of a platinum(IV) anticancer prodrug with selectivity towards LHRH-receptor positive cancer cells. Inorg. Chem. 58, 11076–11084
Chen, B., Kong, W., Wang, N., Zhu, G.*, and Wang, F.* (2019) Oleylamine-mediated synthesis of small NaYbF4 nanoparticles with tunable size. Chem. Mater. 31, 4779–4786
Li, C., Li, T., Huang, L.*, Yang, M.*, and Zhu, G.* (2019) Self-assembled lipid nanoparticles for ratiometric codelivery of cisplatin and siRNA targeting XPF to combat drug resistance in lung cancer. Chem. Asian J. 14, 1570–1576
Wang, A., Kang, F., Wang, Z., Shao, Q., Li, Z., Zhu, G., Lu, J., and Li, Y. Y. (2019) Facile synthesis of nitrogen-rich carbon dots as fertilizers for mung bean sprouts. Adv. Sustainable Syst. 3, 1800132
Wang, Z., Deng, Z., and Zhu, G.* (2019) Emerging platinum(IV) prodrugs to combat cisplatin resistance: From isolated cancer cells to tumor microenvironment. Dalton Trans. 48, 2536–2544
[Invited Review and Front Cover Article]
2018
Li, Y., Yu, W.-K., Chen, L., Chan, Y.-S., Liu, D., Fong, C.-C., Xu, T., Zhu, G., Sun, D., Yang, M. (2018) Electrotaxis of tumor-initiating cells of H1975 lung adenocarcinoma cells is associated with both activation of stretchactivated cation channels (SACCs) and internal calcium release. Bioelectrochemistry 124, 80–92
Xu, Z., Chan, H. M., Li, C., Wang, Z., Tse, M.-K., Tong, Z., and Zhu, G.* (2018) Synthesis, structure, and cytotoxicity of oxaliplatin-based platinum(IV) anticancer prodrugs bearing one axial fluoride. Inorg. Chem. 57, 8227–8235
Ma, L., Wang, N., Ma, R., Li, C., Xu, Z., Tse, M.-K., and Zhu, G.* (2018) Monochalcoplatin: an actively transported, quickly reducible, and highly potent Pt(IV) anticancer prodrug. Angew. Chem. Int. Ed. 57, 9098–9102
[Highlighted in X-MOL (in Chinese)]
Ma, L., Lin, X., Li, C., Xu, Z., Chan, C.-Y., Tse, M.-K., Shi, P., and Zhu, G.* (2018) A cancer cell-selective and low-toxic bifunctional heterodinuclear Pt(IV)-Ru(II) anticancer prodrug. Inorg. Chem. 57, 2917–2924
Wang, N., Wang, Z., Xu, Z., Chen, X., and Zhu, G.* (2018) A cisplatin-loaded immuno-chemotherapeutic nanohybrid bearing immune checkpoint inhibitors for enhanced cervical cancer therapy. Angew. Chem. Int. Ed. 57, 3426–3430
[Highlighted in X-MOL (in Chinese)]
Ai, F., Wang, N., Zhang, X., Sun, T., Zhu, Q., Kong, W., Wang, F.*, and Zhu, G.* (2018) An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy. Nanoscale 10, 4432–4441
Sun, T., Ai, F., Zhu, G.*, and Wang, F.* (2018) Recent progress in upconversion in nanostructured materials: From optical tuning to biomedical applications. Chem. Asian J. 13, 373–385
[Invited Review; Featured as a Front Cover of Volume 13, Issue 4 in February 2018]
2017
Yan. L., Chen, X., Wang, Z., Zhang, X., Zhu, X., Zhou, M., Chen, W., Huang, L., Roy, V.A.L., Yu, P.K.N., Zhu, G., and Zhang, W. (2017) Size controllable and surface tunable zeolitic imidazolate framework-8 (ZIF-8)-poly(acrylic acid sodium salt) (PAAS) nanocomposites for pH responsive drug release and enhanced in vivo cancer treatment. ACS Appl. Mater. Interfaces 9, 32990–33000
Li, C., Ip, K.-W., Man. W.-L., Song, D., He, M.-L., Yiu, S.-M., Lau, T.-C.,* and Zhu, G.* (2017) Cytotoxic (salen)ruthenium(III) anticancer complexes exhibit different modes of cell death directed by axial ligands. Chem. Sci. 8, 6865–6870
Lan, M., Zhao, S., Zhang, Z., Yan, L., Guo, L., Niu, G., Zhang, J., Zhao, J., Zhang, H., Wang, P., Zhu, G., Lee, C.-S., and Zhang, W. (2017) Two-photon-excited near-infrared emissive carbon dots as multifunctional agents for fluorescence imaging and photothermal therapy. Nano Res. 10, 3113–3123
Li, W., Xu, Z., Xu, B., Chan, C. Y., Lin, X., Wang, Y., Chen, G., Wang, Z., Yuan, Q., Zhu, G., Sun, H., Wu, W., and Shi, P. (2017) Investigation of the subcellular neurotoxicity of amyloid-β using a device integrating microfluidic perfusion and chemotactic guidance. Adv. Healthc. Mater. 6, 1600895
Yan, L., Wang, Z., Chen, X., Gou, X.-J., Zhang, Z., Zhu, X., Lan, M., Chen, W., Zhu, G., and Zhang, W. (2017) Firmly anchored photosensitizer Chlorin e6 to layered double hydroxide nanoflakes for highly efficient photodynamic therapy in vivo.Chem. Commun. 53, 2339–2342
Xu, Z., Li, C., Tong, Z., Ma, L., and Zhu, G.* (2017) Halogenated Pt(IV) complexes from N-halosuccinimide oxidation of Pt(II) antitumor drugs: Synthesis, mechanistic investigation, and cytotoxicity. Eur. J. Inorg. Chem. 12, 1706–1712
[Very Important Paper; Invited contribution to EurJIC’s Cluster Issue on "Metal Anticancer Complexes - Activity, Mechanism of Action and Future Perspectives]
Yu, W.-K., Wang, Z., Fong, C.-C., Liu, D, Yip, T.-C., Au, S.-K., Zhu, G.*, and Yang, M.* (2017) Chemoresistant lung cancer stem cells display high DNA repair capability to remove cisplatin-induced DNA damage. Br. J. Pharmacol. 174, 302–313
Kong, W., Sun, T., Chen, B., Chen, X., Ai, F., Zhu, X., Li, M., Zhang, W., Zhu, G., and Wang, F. (2017) A general strategy for ligand exchange on upconversion nanoparticles, Inorg. Chem. 56, 872–877
2016
Wang, Z., Xu, Z., and Zhu, G.* (2016) A platinum(IV) anticancer prodrug targeting nucleotide excision repair to overcome cisplatin resistance. Angew. Chem. Int. Ed. 55, 15564–15568
[Very Important Paper and Back Cover Article]
Ma, L., Ma, R., Wang, Z., Yiu, S.-M., and Zhu, G.* (2016) Heterodinuclear Pt(IV)-Ru(II) anticancer prodrugs to combat both drug resistance and tumor metastasis. Chem. Commun. 52, 10735–10738
Ai, F., Sun, T., Xu, Z., Wang, Z., Kong, W., To, M. W., Wang, F., and Zhu, G.* (2016) An upconversion nanoplatform for simultaneous photodynamic therapy and Pt chemotherapy to combat cisplatin resistance. Dalton Trans. 45, 13052–13060
[Invited contribution to the Metallodrugs Themed Issue; Featured as a Back Cover Article of Volume 45, Issue 33 in August 2016]
Chen, W., Zhang, X., Ai, F., Yang, X., Zhu, G.* and Wang, F.* (2016) Graphitic carbon nanocubes derived from ZIF-8 for photothermal therapy. Inorg. Chem. 55, 5750–5752
Zhang, J., Chen, W., Kalytchuk, S., Chen, R., Adachi, C., Chen, Z., Rogach, A. L., Zhu, G., Yu, P. K. N., Zhang, W., Zhang, X., and Lee, C.-S. (2016) Self-assembly of electron donor-acceptor based carbazole derivatives: Novel fluorescent organic nanoprobes for both one-photon and two-photon cellular imaging. ACS Appl. Mater. Interfaces 8, 11355–11365
Zhang, X., Ai, F., Sun, T., Wang, F., and Zhu, G.* (2016) A multimodal upconversion nanoplatform with mitochondria-targeted property for improved photodynamic therapy of cancer cells. Inorg. Chem. 55, 3872–3880
Wang, D. D., Lee, V. H. F., Zhu, G., Ma, L., Zou, B., and Yan, H. (2016) Selectivity profile of afatinib for EGFR-mutated non-small-cell lung cancer. Mol. Biosyst. 12, 1552–1563
Zhu, X., Yuen, M. F., Ai, F., Yan, L., Yang, Y., Yu, K. N., Zhu, G.*, Zhang, W.*, and Chen, X.* (2016) The potential influence of using diamond nanoneedle arrays for facilitated intracellular delivery on cell physiology. Adv. Healthcare Mater. 5, 1157–1168
[Featured as an Inside Front Cover of Volume 5, Issue 10 in May 2016]
2015
Xu, Z., Wang, Z., Yiu, S.-M., and Zhu, G.* (2015) Mono- and di-bromo platinum(IV) prodrugs via oxidative bromination: Synthesis, characterization, and cytotoxicity. Dalton Trans. 44, 19918–19926
Zhang, J., Liang, Y.-C., Liu, X., Zhu, X., Yan, L., Li, S., Yang, X., Zhu, G., Rogach, A. L., Yu, P. K. N., Shi, P., Tu, L. C., Chang, C.-C., Zhang, X., Chen, X., Zhang, W., and Lee, C.-S. (2015) Self-monitoring and self-delivery of photosensitizer-doped nanoparticles for highly effective combination cancer therapy in vitro and in vivo. ACS Nano 9, 9741–9756
Zhu, X., Kwok, S. Y., Yuen, M. F., Yan, L., Chen, W., Yang, Y., Wang, Z., Yu, K. N., Zhu, G.*, Zhang, W.*, and Chen, X.* (2015) Dense diamond nanoneedle arrays for enhanced delivery of drug molecules to cell lines. J. Mater. Sci. 50, 7800–7807
Wang, Z., Ma, R., Yan, L., Chen. X., and Zhu, G.* (2015) Combined chemotherapy and photodynamic therapy using layered double hydroxide nanoparticles to conquer cisplatin resistance. Chem. Commun. 51, 11587–11590
Ai, F., Ju, Q., Zhang, X., Chen, X., Wang, F.*, and Zhu, G.* (2015) A core-shell-shell nanoplatform upconverting near-infrared light at 808 nm for luminescence imaging and photodynamic therapy of cancer. Sci. Rep. 5, 10785
[Top 100 (1%) cited Scientific Reports articles in 2015]
Ma, R., Wang, Y., Yan, L., Ma, L., Chan, H. C., Chiu, S. K., Chen, X., and Zhu, G.* (2015) Efficient co-delivery of Pt(IV) prodrug and p53 activator as a convenient strategy to enhance the anticancer activity of cisplatin. Chem. Commun. 51, 7859–7862
Ju, Q., Chen, X., Ai, F., Peng, D., Li, W., Shi, P., Zhu, G., and Wang, F.* (2015) An upconversion nanoprobe operating in the first biological window. J. Mater. Chem. B 3, 3548–3555
Ma, L., Ma, R., Wang, Y., Zhu, X., Zhang, J., Chan, H. C., Chen, X., Zhang, W., Chiu, S.-K., and Zhu, G.* (2015) Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action.Chem. Commun. 51, 6301–6304
[Featured as a Back Cover Article of Volume 51, Issue 29 in April 2015]
Wang, Z., Ai, F., Wang, Z., Zhang, W., Zhu, G.*, Lin, Z.*, and Sun, J.* (2015) Organocatalytic asymmetric synthesis of 1,1-diarylethanes by transfer hydrogenation. J. Am. Chem. Soc. 137, 383–389
2014
Wang, B., Wang, Z., Ai, F., Tang, W. K., and Zhu, G.* (2014) A monofunctional platinum(II)-based anticancer agent from a salicylanilide derivative: Synthesis, antiproliferative activity, and transcription inhibition. J. Inorg. Biochem. 142C, 118–125
Wang, Y., Yang, Y., Yan, L., Kwok, S. Y., Li, W., Wang, Z., Zhu, X., Zhu, G., Zhang, W., Chen, X., and Shi, P. (2014) Poking cells for efficient vector-free intracellular delivery. Nat. Commun. 5, 4466
Ma, R., Wang, Z., Yan, L., Chen, X.*, and Zhu, G.* (2014) Novel Pt-loaded layered double hydroxide nanoparticles for efficient and cancer-cell specific delivery of a cisplatin prodrug. J. Mater. Chem. B 2, 4868–4875
Chen, W., Wang, C., Yan, L., Huang, L., Zhu, X., Chen, B., Sant, H. J., Niu, X., Zhu, G., Yu, K. N., Roy, V.A.L., Gale, B. K., Chen, X. (2014) Improved polyvinylpyrrolidone microneedle arrays with non-stoichimetric cyclodextrin. J. Mater. Chem. B 2, 1699–1705
Wang, B., Qian, H., Yiu, S.-M., Sun, J., and Zhu, G.* (2014) Platinated benzonaphthyridone is a stronger inhibitor of poly(ADP-ribose) polymerase-1 and a more potent anticancer agent than is the parent inhibitor. Eur. J. Med. Chem. 71, 366–373
Wang, Z., Qian, H., Yiu, S.-M., Sun, J., and Zhu, G.* (2014) Multi-targeted organometallic ruthenium(II)-arene anticancer complexes bearing inhibitors of poly(ADP-ribose) polymerase-1: A strategy to improve cytotoxicity. J. Inorg. Biochem. 131, 47–55
Yan, L., Raphael, A. P., Wang, B., Zhu, G., Chen, W., Sant, H. J., Gale, B. K., Prow, T. W., Chen, X.* (2014) Nanocomposite strengthened dissolving microneedles for improved transdermal delivery to human skin. Adv. Healthcare Mater. 3, 555–564
2013
Wen, H., Zhu, H., Chen, X., Hung, T. F., Wang, B., Zhu, G., Yu, S. F., and Wang, F.* (2013) Upconverting near-infrared light through energy management in core-shell-shell nanoparticles. Angew. Chem. Int. Ed. 52, 13419–13423
Yan, L., Chen, W., Zhu, X., Huang, L., Wang, Z., Zhu, G., Roy, V. A. L., Yu, K. N., and Chen, X.* (2013) Folic acid conjugated self-assembled layered double hydroxides nanoparticles for high-efficacy-targeted drug delivery. Chem. Commun. 49, 10938–10940
Zhu, G., Song, L., and Lippard, S. J. (2013) Visualizing inhibition of nucleosome mobility and transcription by cisplatin-DNA interstrand crosslinks in live mammalian cells. Cancer Res. 73, 4451–4460
Chen, X.*, Zhu, G.*, Yang, Y., Wang, B., Yan, L., Zhang, K. Y., Lo, K. K. W. and Zhang, W.* (2013) A diamond nanoneedle patch for potential high-throughput intracellular delivery. Adv. Healthcare Mater. 2, 1103–1107
[Featured as a Cover Article of Volume 2, Issue 8 in August 2013]
Chen, Z., Wang, B., Wang, Z., Zhu, G.* and Sun, J.* (2013) Complex bioactive alkaloid-type polycycles through efficient catalytic asymmetric multicomponent aza-diels–alder reaction of indoles with oxetane as directing group. Angew. Chem. Int. Ed. 52, 2027–2031
[Highlighted in SYNTACTS: https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0032-1318210]
2012 and before
Zhu, G., Myint, M., Ang, W. H., Song, L. and Lippard, S. J. (2012) Monofunctional platinum-DNA adducts are strong inhibitors of transcription and substrates for nucleotide excision repair in live mammalian cells. Cancer Res. 72, 790–800
Daghestani, H. N., Zhu, G., Johnston, P. A., Shinde, S. N., Brodsky, J. L., Vallee, R. B., and Day, B. W. (2012) Characterization of inhibitors of glucocorticoid receptor nuclear translocation: A model of cytoplasmic dynein-mediated cargo transport. Assay Drug Dev. Technol. 10, 46–60
Graf, N., Ang, W. H., Zhu, G., Myint, M., and Lippard, S. J. (2011) Role of endonucleases XPF and XPG in nucleotide excision repair of platinated DNA and cisplatin/oxaliplatin cytotoxicity in osteosarcoma cells. ChemBioChem 12, 1115–1123
Zhu, G., Chang, P., and Lippard, S. J. (2010) Recognition of platinum damage by poly(ADP-ribose) polymerase. Biochemistry 49, 6177–6183
Wang, D., Zhu, G., Huang, X. and Lippard, S. J. (2010) Structural basis of RNA polymerase II transcription inhibition by pyriplatin, a monofunctional anticancer agent. Proc. Natl. Acad. Sci. U.S.A. 107, 9584–9589
[Highlighted in Faculty of 1000 Biology: http://f1000biology.com/article/id/4041963/evaluation; SSRL Science Highlight - January 2011]
Vogt, A., McPherson, P. A., Shen, X., Balachandran, R., Zhu, G., Raccor, B. S., Nelson, S. G., Tsang, M., and Day, B. W. (2009) High-content analysis of cancer-cell-specific apoptosis and inhibition of in vivo angiogenesis by synthetic (-)-pironetin and analogs. Chem. Biol. Drug Des. 74, 358–368
Zhu, G., and Lippard, S. J. (2009) Photoaffinity labeling reveals nuclear proteins that uniquely recognize cisplatin-DNA interstrand cross-links. Biochemistry 48, 4916-4925
[News story describing this work was highlighted in Rouzer, C. A. (2009) Chem. Res. Toxicol. 22, 1215-1216]
Wright, C. M., Chovatiya, R. J., Jameson, N. E., Turner, D. M., Zhu, G., Werner, S., Huryn, D. M., Pipas, J. M., Day, B. W., Wipf, P., and Brodsky, J. L. (2008) Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. Bioorg. Med. Chem. 16, 3291–3301
Wang, Z., McPherson, P. A., Raccor, B. S., Balachandran, R., Zhu, G., Day, B. W., Vogt, A., and Wipf, P. (2007) Structure-activity and high-content imaging analyses of novel tubulysins. Chem. Biol. Drug Des. 70, 75–86
Zhu, G., Yang, F., Balachandran, R., Höök, P., Vallee, R. B., Curran, D. P., and Day, B. W. (2006) Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. J. Med. Chem. 49, 2063–2076
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